What's New This Month
April 2025
Apr 10
New Entry
Age-Related Decline Replacement Protocol added to the protocols section β a 10-compound, three-layer protocol addressing testosterone, GH axis, NAD+, GHK-Cu, mitochondrial function, thymic senescence, and Klotho decline. Includes comprehensive blood work schedule and both male and female dose references. The most complete anti-ageing protocol framework on the site.
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Apr 10
New Calendar
Age-Related Decline Replacement Calendar β the 6th protocol calendar, showing the full 12-month schedule across all three layers with phase bars, blood work months, and a start-month adjuster so you can begin any time of year.
β View calendar
Apr 10
Entry Updated
NAD+/NMN entry updated with a new "Administration Routes" section covering oral, IV infusion, IM injection, and intranasal delivery β including bioavailability comparison, when each route is appropriate, and the important note that oral supplement powder is never suitable for injection.
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Apr 10
Entry Updated
BPC-157 entry now includes a full SubQ vs IM vs Oral route comparison β when to use each, angle, needle gauge, and the route decision guide: gut issues β oral Arg-BPC-157, muscle tears β IM, systemic/tendon β SubQ.
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Apr 10
New Section
Highly Experimental Protocols added to the protocols page β 6 frontier protocols including the Senolytic Clearance Stack (FOXO4-DRI + D+Q), Mitochondrial Maximalist, Cognitive Maximalist (Dihexa + Cerebrolysin), Follistatin + Klotho, SLU-PP-332 Exercise Mimetic, and the Longevity Maximalist. Each card includes "Why people run this," "What we don't know," and "Minimum before attempting."
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Apr 10
Lab Testing
Community Lab Testing database launched β submit your independent Janoshik, Colmaric, or other lab results for the community. Database currently seeded with 6 example results showing the format. First community submissions expected this month.
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MR
Member_R Β·
Chronic Achilles tendinopathy β 8 months of pain resolved in 10 weeks
Had chronic right Achilles tendinopathy following a half marathon in October 2023. Standard physio, rest, and eccentric loading helped marginally but pain persisted at a 5-6/10 during running. Started BPC-157 SubQ closest to the injury site, added TB-500 2Γ weekly for systemic support. Weeks 1-3: Noticeable reduction in morning stiffness. Weeks 4-6: Pain during running dropped from 5-6/10 to 2-3/10. Weeks 8-12: Essentially pain-free. Returned to full training at week 10. Now 6 months post-protocol with no recurrence. Blood work showed no concerning changes. Would run this protocol again without hesitation for soft tissue injuries.
SL
Member_SL Β·
Foundation layer of the age-related decline protocol β 6 month check-in
Running the foundation layer of the age-related decline protocol from this reference. Blood work at baseline and 3 months. IGF-1 went from 98 to 142 ng/mL on 200mcg Sermorelin nightly β good response. GHK-Cu topical daily + SubQ 3Γ/week, skin texture measurably improved by both my own assessment and my aesthetician. NMN 500mg daily β NAD+ blood test at 8 weeks showed elevation from 31 to 58 Β΅mol/L. Subjective: Sleep quality significantly improved (tracking with Oura β deep sleep up ~22 minutes/night average). Energy more consistent. Hair quality improved noticeably. No adverse effects across 6 months. About to add Thymosin Ξ±-1 for the spring course. Will report back.
TK
Member_TK Β·
Semaglutide titration β what actually worked for managing side effects
Used the titration protocol from this reference. The slow titration (4 weeks at each dose level) made a significant difference to tolerability vs the aggressive titrations I'd read about elsewhere. What actually worked for nausea: injecting Friday evening meant Saturday discomfort but back to normal Monday for work. High protein meals, smaller portions, ginger tea. Avoided fatty foods for 48h post-injection. Results at 16 weeks: 14.2kg lost. Energy excellent. No muscle loss (maintained training throughout, protein at 1.8g/kg). What I wish I'd known: the constipation is real and consistent β magnesium glycinate 400mg nightly fixed it completely. The reference prep guide on timing and titration was more useful than anything else I found.
JP
Member_JP Β·
Cognitive stack β Semax strong, Selank mild, combination issues
Ran the cognitive stack from the reference. Semax effect was clear and noticeable β focus improved significantly, word retrieval faster, work output measurably higher. Selank alone I found mild β mild anxiety reduction, not dramatic. The combination issue: running both same-day I found overstimulating β slight agitation and disrupted sleep. Switched to alternating days: Semax Monday/Wednesday/Friday, Selank Tuesday/Thursday. That resolved it. Cambridge Brain Sciences scores: Baseline vs 8-week showed improvements in working memory (+12%) and reasoning (+8%) β modest but consistent. Would I repeat: Yes, but Semax-dominant with Selank as needed rather than rigid daily protocol. The reference note about combining carefully was right β I should have read it more carefully before starting.
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AK
Member_AK
BPC-157 Β· Dosing questions
3 days ago
Oral vs SubQ for gut symptoms β which worked for you?
Running BPC-157 for what I think is leaky gut β bloating, food sensitivities, occasional cramping. The entry says oral for gut issues but I've also seen people say SubQ works systemically. Anyone with gut issues specifically β did you go oral Arg-BPC-157 or SubQ, and what did you find? Dose and duration would help.
ML
Member_ML
BPC-157 Β· Protocol timing
1 week ago
Running BPC-157 alongside Sermorelin β timing advice?
Following the anti-ageing male calendar and running Sermorelin nightly. About to add BPC-157 for a knee injury. The mixing guide says caution on combining β should I inject them at different times or just keep them separate syringes same injection window?
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Share your experience honestly β what you ran, what happened, what your blood work showed. The most useful reports include specific doses, duration, and measurable outcomes. Anonymous β your pseudonym never reveals personal identity.
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